The adverse effects of 17β-estradiol immersion during gonadal differentiation on ovarian development of female Takifugu rubripes
نویسندگان
چکیده
Estrogen exposure during early-life stages has been found to delay ovarian development in female fish, even after a long-term depuration period. However, the mechanisms underlying disordered remain unclear. In this study, larvae of tiger puffer Takifugu rubripes were exposed 0 (control) and 10 μg/L 17β-estradiol (E2) from 20 90 days post-hatch (dph) maintained clear seawater until 180 dph. Genetic females collected at dph identified by analyzing sex-associated SNP. Then, structure, gonadosomatic index (GSI), maximum follicle area mRNA levels genes involving cell cycle ( ckd2 , ckd4 cdk6 ccna2 ccnd2 cdkn1b cdkn2c ), meiosis initiation sycp3 rec8 spo11 dmc1 formatiaon bmp2 hnrnpk hmp15 gdf9 nobox figla ) apoptosis bax bcl-2 analyzed between control E2-exposed females. The results show that, no structure difference ovaries was observed E2-treated dph, but primary growth follicles be fewer number than Both weight GSI significant lower while there different neither or Additionally, E2 suppressed expression dmc1, those showed with reduced might result disrupted meiosis, suppression affected formation. abnormal formation further promote as indicated decrease which ultimately contributed less low value
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ژورنال
عنوان ژورنال: Frontiers in Marine Science
سال: 2023
ISSN: ['2296-7745']
DOI: https://doi.org/10.3389/fmars.2023.1131041